'Spider-goats' start work on wonder web
By Roger Highfield, Science Editor
(Filed: 18/01/2002)
A HERD of goats containing spider genes is about to be milked for the ingredients of spider silk to mass-produce one of nature's most sought-after materials.
Scientists have for the first time spun synthetic spider silk fibres with properties approaching the real thing, paving the way for their use in artificial tendons, medical sutures, biodegradable fishing lines, soft body armour and a host of other applications.
Webster and Peter, genetically altered goats unveiled today by the Canadian company Nexia, are the founders of a GM herd whose offspring will produce spider silk protein in their milk that can be collected, purified and spun into the fibres. Females will begin mass-producing spider milk in the second quarter of this year for a variety of military and industrial uses.
Spider silk has long been admired by material scientists for its unique combination of toughness, lightness and biodegradability. Dragline silk, which comprises the radiating spokes of a spider web, is stronger than the synthetic fibre Kevlar, stretches better than nylon and, weight for weight, is five times stronger than steel.
These incredible qualities are the product of 400 million years of evolution. Now spider yarn has been spun by the US Army and the company Nexia Biotechnologies of Montreal, marking a milestone in efforts to ape arachnids.
The work "opens up a lot of things on the practical level and on a research level," said Dr Randy Lewis, a spider silk expert at the University of Wyoming, Laramie. Dr Jeffrey Turner, President of Nexia, said: "Mimicking spider silk properties has been the holy grail of material science and now we've been able to make useful fibres.
"It's incredible that a tiny animal found literally in your backyard can create such an amazing material by using only amino acids, the same building blocks used to make skin and hair."
Spider silk is a material science wonder, "a self-assembling, biodegradable, high-performance, nanofibre structure one-tenth the width of a human hair that can stop a bee travelling at 20 miles per hour without breaking. Spider silk has dwarfed man's achievements in material science to date."
Today, in the journal Science, the scientists describe details of the production of different dragline spider silk proteins. First, they turned cells from cows' lungs and baby hamster kidneys into silk protein "factories" by giving them genes from two different species of orb-weaving spiders whose dragline silks have been documented to be among the strongest
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