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Inexpensive Treatment For Many Forms of Cancer News Item
#84145
01/17/07 03:39 PM
01/17/07 03:39 PM
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I read this from the following link: http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20070116/cancer_dca_070116/20070116/ A small, non-toxic molecule may soon be available as an inexpensive treatment for many forms of cancer, including lung, breast and brain tumours, say University of Alberta researchers.
But there's a catch: the drug isn't patented, and pharmaceutical companies may not be interested in funding further research if the treatment won't make them a profit.
In findings that "astounded" the researchers, the molecule known as DCA was shown to shrink lung, breast and brain tumours in both animal and human tissue experiments.
"You typically get this eureka type of feeling. It's the most exciting thing a scientist can get," Dr. Evangelos Michelakis, a professor at the University of Alberta department of medicine and a key study author, told CTV News.
The study was published Tuesday in the journal Cancer Cell.
The molecule appears to repair the damage that cancer cells cause to mitochondria, the units that convert food into energy.
"Cancer cells actively suppress their mitochondria, which alters their metabolism, and this appears to offer cancer cells a significant advantage in growth compared to normal cells, as well as protection from many standard chemotherapies," Michelakis said in a written statement.
As mitochondria regulate cell death, cancer cells can resist being killed off.
For years, DCA -- or dichloroacetate -- has been used to treat children with inborn errors of metabolism due to mitochondrial diseases.
Until recently, researchers believed damage to mitochondria in cancer cells was permanent.
But Michelakis questioned this theory and began testing DCA, which activates a critical enzyme, as a way to "revive" cancer-affected mitochondria.
He says one of the most exciting things about this compound is that it might be able to treat many different forms of cancer because they all suppress mitochondrial function.
Therefore, DCA can primarily affect the cancer cells without affecting the normal ones.
Researchers also say DCA may prove to be effective because it is a small compound, thus easily absorbed in the body.
After oral intake, it can reach areas in the body that other drugs cannot, making it possible to treat cancer of the brain, for example.
In addition, because DCA has been used in both healthy people and ailing patients with mitochondrial diseases, researchers know it is a relatively non-toxic molecule that can be immediately tested in patients with cancer.
The compound, which is sold both as powder and as a liquid, is widely available at chemistry stores.
But because it's not patented or owned by any drug firm, it would be an inexpensive drug to administer. And researchers may have a difficult time finding money for further research.
Dr. Dario Altieri, of the University of Massachusetts, said the drug is exactly what doctors need because it could limit side-effects for patients. But there are "market considerations" that drug companies would have to take into account.
Michelakis remains hopeful he will be able to secure funding for further research.
"We hope we can attract the interest of universities here in Canada and in the United States," said Michelakis.
With a report from CTV's Avis Favaro and Elizabeth St. Philip
If this is true, then I am concerned about their real concern about finding a cure for cancer.
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Daryl]
#84316
01/21/07 06:41 PM
01/21/07 06:41 PM
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I found this blog on another website:
-----beginning of blog-----
It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs. Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks. DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar. Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis’s experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died (Cancer Cell, DOI: 10.1016/j.ccr.2006.10.020). Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump don’t get enough oxygen for their mitochondria to work properly (see diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis. Crucially, though, mitochondria do another job in cells: they activate apoptosis, the process by which abnormal cells self-destruct. When cells switch mitochondria off, they become “immortal”, outliving other cells in the tumour and so becoming dominant. Once reawakened by DCA, mitochondria reactivate apoptosis and order the abnormal cells to die. “The results are intriguing because they point to a critical role that mitochondria play: they impart a unique trait to cancer cells that can be exploited for cancer therapy,” says Dario Altieri, director of the University of Massachusetts Cancer Center in Worcester. The phenomenon might also explain how secondary cancers form. Glycolysis generates lactic acid, which can break down the collagen matrix holding cells together. This means abnormal cells can be released and float to other parts of the body, where they seed new tumours. DCA can cause pain, numbness and gait disturbances in some patients, but this may be a price worth paying if it turns out to be effective against all cancers. The next step is to run clinical trials of DCA in people with cancer. These may have to be funded by charities, universities and governments: pharmaceutical companies are unlikely to pay because they can’t make money on unpatented medicines. The pay-off is that if DCA does work, it will be easy to manufacture and dirt cheap. Paul Clarke, a cancer cell biologist at the University of Dundee in the UK, says the findings challenge the current assumption that mutations, not metabolism, spark off cancers. “The question is: which comes first?” he says.
-----end of blog-----
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Daryl]
#84317
01/21/07 06:49 PM
01/21/07 06:49 PM
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This really bothers me in the sense that I personally know a person who will soon die of cancer, if she doesn't receive this drug. They took her off chemotherapy as it will no longer help her in this final stage of her cancer.
All this harmful chemotherapy that she went under, when there seems to be a common and cheap drug available that could very well save her life. The sad thing about this is that this is a drug that has been around and used for other medical problems.
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Daryl]
#84324
01/21/07 07:53 PM
01/21/07 07:53 PM
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Active Member 2011
3500+ Member
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Joined: May 2002
Posts: 3,965
Sweden
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This might be worth checking out on the published articles directly...
Galatians 2 21 I do not frustrate the grace of God: for if righteousness come by the law, then Christ is dead in vain.
It is so hazardous to take here a little and there a little. If you put the right little's together you can make the bible teach anything you wish. //Graham Maxwell
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: vastergotland]
#84327
01/21/07 08:16 PM
01/21/07 08:16 PM
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Daryl]
#84330
01/21/07 09:07 PM
01/21/07 09:07 PM
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Active Member 2011
3500+ Member
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Joined: May 2002
Posts: 3,965
Sweden
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It is possible that the Uni has a subscription on the appropriate papers.
Galatians 2 21 I do not frustrate the grace of God: for if righteousness come by the law, then Christ is dead in vain.
It is so hazardous to take here a little and there a little. If you put the right little's together you can make the bible teach anything you wish. //Graham Maxwell
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: vastergotland]
#84371
01/22/07 08:58 PM
01/22/07 08:58 PM
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As this is a commonly used substance, does anybody know where it can be obtained in Canada?
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Daryl]
#85034
02/08/07 08:45 AM
02/08/07 08:45 AM
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Most Dedicated Member
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Joined: Apr 2003
Posts: 2,332
BC, Canada
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I think I would approach my physician about this, and ask to be switched to DCA (dichloroacetate) for treatment. Its worth a shot, speak to a pharmacist as well to ask if they carry this item, there may also be a generic name for it dichloroacetate is the generic name. Worth looking into, especially considering the nature of the person you know Daryl. Do this ASAP!! God Bless, Will
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: Will]
#85037
02/08/07 09:37 AM
02/08/07 09:37 AM
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Well I was looking for a place to post relating to Barbara Kerr's treatment and you must have brought this forum up while I was posting it under:
What Do You Know About Naturalpath Doctors? The Contradiction.
Sorry, sometimes there are subjects that I don't find an appropriate forum topic for.
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Re: Inexpensive Treatment For Many Forms of Cancer News Item
[Re: crater]
#85044
02/08/07 03:29 PM
02/08/07 03:29 PM
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Some topics are related, therefore, it really doesn't matter where you post it. It could have also been posted as a new topic.
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Here is the link to this week's Sabbath School Lesson Study and Discussion Material: Click Here
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